Hormones (especially estrogen) are critically important in human development and tissue repair. However, estrogen’s proliferative effects must be balanced and controlled for optimal health. Therefore, to ensure proper hormonal balance, estrogen synthesis and detoxification should be supported. Estrogen has several downstream metabolites, of which some are beneficial while others possess potentially harmful biological activity. By keeping hormones in balance and ensuring the body can process estrogen properly, cruciferous vegetable metabolites (i.e., I3C and DIM) work together to maintain cellular health.
Indole-3-carbinol (I3C) and diindolylmethane (DIM) are natural metabolites of compounds found in numerous vegetables from the Brassicaceae family. Both I3C and DIM, as well as many other I3C metabolites, have been shown to impact metabolic shifts and cellular activities for improved health outcomes. I3C and DIM have been shown to induce some phase I and phase II biotransformation genes in preclinical models through pathways such as Nrf2, suggesting I3C and DIM may have a role in detoxification. Additionally, both I3C and DIM have been shown in vitro to decrease aromatase expression, the enzyme that converts androgens to estrogen.
*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Serving size: 1 capsule
Servings per container: 60
1 capsule contains:
Vitamin E: 33.5 mg
(from 50 IU as d-Alpha Tocopherol Succinate USP)
Indole-3-carbinol (I3C): 200 mg
Diindolymethane (DIM): 100 mg
Other Ingredients: Hypromellose (Natural Vegetable Capsule), Microcrystalline Cellulose, Magnesium Stearate, Calcium Silicate, Stearic Acid, and Silicon Dioxide.
*This product is formulated to be free of allergens derived from: gluten, corn, yeast, artificial colors and flavors.
Directions: Take 1 capsule per day or as recommended by your health care professional.
Caution: Keep out of the reach of children.
Tamper Evident: Do not use if safety seal is missing or broken.
Storage: Keep tightly closed in a cool, dry place.
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